At least 10 people were killed after two high-speed trains collided in Spain, Spanish media reported on Wednesday. 544 passengers were aboard the trains when they crashed.
The accident prompted rail operator Adif to suspend the line connecting Madrid to the southern Andalusia region.
Government sources told El País that the disaster could "be even worse than Adamuz," another train derailment from January that killed 42 people and left almost 300 wounded.
"Traffic on the Madrid-Andalusia high-speed rail line has been suspended following a rear-end collision between two trains," Adif said in a message posted on X/Twitter.
A Renfe and an Iryo train crashed just after 9 a.m., causing two Iryo wagons to derail, a government spokesperson for the Castilla-La Mancha region said, adding that the cause and number of injuries were still being determined.
Rail operator Adif said the incident occurred between the towns of Mora and Orgaz, and involved a Renfe and an Iryo high-speed train traveling from Madrid to Seville.
Manuel Galan, the mayor of Urda near the central city of Toledo, said he had been asked by emergency services to prepare a sports hall to accommodate the injured.
Fourth major train crash in Spain this year
In January of this year, two high-speed trains crashed in Adamuz, near Cordoba, in southern Spain, killing 46 people.
The crash was one of Europe's largest-ever train disasters.
The same week in January, two other train derailments occurred in Spain.
James Genn contributed to this report.